@article{ref1,
title="Inflammasome: its role in traumatic brain and spinal cord injury",
journal="Journal of cellular physiology",
year="2018",
author="Mortezaee, Keywan and Khanlarkhani, Neda and Beyer, Cordian and Zendedel, Adib",
volume="233",
number="7",
pages="5160-5169",
abstract="Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to neuropathological conditions which have in consequence the initiation of pro-inflammatory cytokine production. Neuroinflammation plays a key role in the secondary phase of both TBI and SCI after initial cell death. Activation of cytoplasmic inflammasome complexes is regarded as the essential step of neuroinflammation and a key trigger for neuronal death called pyroptosis. Inflammasome complexes are involved in activation of caspase-1 which catalyzes the cleavage of pro-interleukins into their active forms (including interleukin-18 (IL-18) and IL-1β). The focus of this article is to discuss the time-course and regulation of inflammasome assembly and activation during TBI and SCI and their targeting in designing therapeutic approaches. We particularly focus on the inflammasomes NLRP1 and NLRP3 which play a pivotal function during TBI and SCI in the central nervous system (CNS). This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0021-9541",
doi="10.1002/jcp.26287",
url="http://dx.doi.org/10.1002/jcp.26287"
}