@article{ref1,
title="Chemical burns of the eye: the role of retinal injury and new therapeutic possibilities",
journal="Cornea",
year="2018",
author="Dohlman, Claes H. and Cade, Fabiano and Regatieri, Caio V. and Zhou, Chengxin and Lei, Fengyang and Crnej, Alja and Harissi-Dagher, Mona and Robert, Marie-Claude and Papaliodis, George N. and Chen, Dongfeng and Aquavella, James V. and Akpek, Esen K. and Aldave, Anthony J. and Sippel, Kimberly C. and DʼAmico, Donald J. and Dohlman, Jan G. and Fagerholm, Per and Wang, Liqiang and Shen, Lucy Q. and González-Andrades, Miguel and Chodosh, James and Kenyon, Kenneth R. and Foster, C. Stephen and Pineda, Roberto and Melki, Samir and Colby, Kathryn A. and Ciolino, Joseph B. and Vavvas, Demetrios G. and Kinoshita, Shigeru and Dana, Reza and Paschalis, Eleftherios I.",
volume="37",
number="2",
pages="248-251",
abstract="PURPOSE: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. <br><br>METHODS: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. <br><br>RESULTS: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells. Prompt anti-TNF-α treatment is markedly neuroprotective. Long term profound reduction of the intraocular pressure is also vital. <br><br>CONCLUSION: A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state.<p /> <p>Language: en</p>",
language="en",
issn="0277-3740",
doi="10.1097/ICO.0000000000001438",
url="http://dx.doi.org/10.1097/ICO.0000000000001438"
}