@article{ref1,
title="Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury",
journal="Clinical and experimental emergency medicine",
year="2017",
author="Jones, Alastair and Jarvis, Paul",
volume="4",
number="3",
pages="121-127",
abstract="Head injury is a common presenting complaint amongst emergency department patients. To date, there has been no widespread utilization of neuro-biomarkers to aid the diagnosis of traumatic brain injury. This review article explores which neuro-biomarkers could be used in the emergency department in aiding the clinical diagnosis of mild traumatic brain injury. Based on the available evidence, the most promising neuro-biomarkers appear to be Glial fibrillary acidic protein (GFAP) and Ubiquitin C-Terminal Hydrolase Isozyme L1 (UCH-L1) as these show significant rises in peripheral blood levels shortly after injury and these have been demonstrated to correlate with long-term clinical outcomes. Treatment strategies for minor traumatic brain injury in the emergency department setting are not well developed. The introduction of blood neuro-biomarkers could reduce unnecessary radiation exposure and provide an opportunity to improve the care of this patient group.<p /> <p>Language: en</p>",
language="en",
issn="2383-4625",
doi="10.15441/ceem.17.226",
url="http://dx.doi.org/10.15441/ceem.17.226"
}