@article{ref1,
title="The effect of perindopril on postural instability in older people with a history of falls-a randomised controlled trial",
journal="Age and ageing",
year="2018",
author="Sumukadas, Deepa and Price, Rosemary and McMurdo, Marion E. T. and Rauchhaus, Petra and Struthers, Allan and McSwiggan, Stephen and Arnold, Graham and Abboud, Rami and Witham, Miles",
volume="47",
number="1",
pages="75-81",
abstract="DESIGN: double-blind, parallel group, placebo-controlled randomised trial. <br><br>METHODS: we recruited people aged >65 years with at least one fall in the previous year. Participants received 4 mg perindopril or placebo daily for 15 weeks. The primary outcome was the between-group difference in force-plate measured anteroposterior (AP) sway at 15 weeks. Secondary outcomes included other measures of postural sway, limits of stability during maximal forward, right and left leaning, blood pressure, muscle strength, 6-min walk distance and falls. The primary outcome was assessed using two-way ANOVA, adjusted for baseline factors. <br><br>RESULTS: we randomised 80 participants. Mean age was 78.0 (SD 7.4) years; 60 (75%) were female. About 77/80 (96%) completed the trial. At 15 weeks there were no significant between-group differences in AP sway with eyes open (mean difference 0 mm, 95% CI -8 to 7 mm, P = 0.91) or eyes closed (mean difference 2 mm, 95% CI -7 to 12 mm, P = 0.59); no differences in other measures of postural stability, muscle strength or function. About 16/40 (42%) of patients in each group had orthostatic hypotension at follow-up. The median number (IQR) of falls was 1 (0,4) in the perindopril versus 1 (0,2) in the placebo group (P = 0.24). <br><br>CONCLUSIONS: perindopril did not improve postural sway in older people at risk of falls. CLINICAL TRIALS REGISTRATION: ISRCTN58995463.<p /> <p>Language: en</p>",
language="en",
issn="0002-0729",
doi="10.1093/ageing/afx127",
url="http://dx.doi.org/10.1093/ageing/afx127"
}