@article{ref1,
title="Changes in [18F]fluorodeoxyglucose activities in a shockwave-induced traumatic brain injury model using lithotripsy",
journal="Journal of neurotrauma",
year="2018",
author="Divani, Afshin Andre and Phan, Jenny-Ann and Salazar, Pascal and SantaCruz, Karen S. and Bachour, Ornina and Mahmoudi, Javad and Zhu, Xiao-Hong and Pomper, Martin",
volume="35",
number="1",
pages="187-194",
abstract="We present a longitudinal study of cerebral metabolism using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in a rat model of shockwave-induced traumatic brain injury (SW-TBI). Anesthetized rats received 5 or 10 shockwave pulses to the right anterior lateral or dorsal frontal regions using shockwave lithotripsy. Animals were scanned for FDG uptake at baseline, 3 hours post-injury, and 3 days post-injury, using a small animal PET/CT scanner. FDG uptake at all time points was quantified as the ratio of brain activity relative to peripheral activity in the left ventricle (LV) in the heart (Abrain/ALV) for the entire brain, each hemisphere, and four cortices (motor, cingulate, somatosensory, and restrosplenial). The mixed-designed models ANOVA for the hemispheric and global FDG uptake ratio showed a significant effect of the time-of-scan (P=0.038) and measured region (P=6.12e-09). We also observed a significant effect of the time-of-scan (P=0.046) and measured region (P=2.28e-09) for the FDG uptake ratio in four cortical regions. None of the measurements (global or local) showed a significant effect for the number of shockwave pulses (5 or 10) or shockwave location (lateral or dorsal frontal regions). Our data suggest that SW-TBI causes hypermetabolism on the impact side of the rat brain at 3 hours post-injury compared to the baseline measurements. However, the increase in FDG uptake by day 3 post-injury was not significant. Further studies on post-TBI metabolic changes are needed to understand better the pathophysiology of the injury.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="",
url="http://dx.doi.org/"
}