@article{ref1,
title="Impact of extended monitoring-guided intensive care on outcome after severe traumatic brain injury: a prospective multicentre cohort study (PariS-TBI study)",
journal="Brain injury",
year="2017",
author="Mateo, Joaquim and Payen, Didier and Ghout, Idir and Vallée, Fabrice and Lescot, Thomas and Welschbillig, Stephane and Tazarourte, Karim and Azouvi, Philippe and Weiss, Jean-Jacques and Aegerter, Philippe and Vigue, Bernard",
volume="31",
number="12",
pages="1642-1650",
abstract="OBJECTIVE: We evaluated whether an integrated monitoring with systemic and specific monitoring affect mortality and disability in adults with severe traumatic brain injury (sTBI). <br><br>METHODS: Adults with severeTBI (Glasgow Coma Scale [GCS] ≤ 8) admitted alive in intensive care units (ICUs) were prospectively included. Primary endpoints were in-hospital 30-day mortality and extended Glasgow outcome score (GOSE) at 3 years. Association with the intensity of monitoring and outcome was studied by comparing a high level of monitoring (HLM) (systemic and ≥3 specific monitoring) and low level of monitoring (LLM) (systemic and 0-2 specific monitoring) and using inverse probability weighting procedure. <br><br>RESULTS: 476 patients were included and IPW was used to improve the balance between the two groups of treatments (HLM/LMM). Overall hospital mortality (at 30 days) was 43%, being significantly lower in HLM than LLM group (27% vs. 53%: RR, 1.63: 95% CI: 1.23-2.15). The 14-day hospital mortality was also lower in the HLM group than expected, based upon the CRASH prediction model (35%). At 3 years, disability was not significantly different between the monitoring groups. <br><br>CONCLUSIONS: After adjustment, HLM group improved short-term mortality but did not show any improvement in the 3-year outcome compared with LLM.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2017.1370554",
url="http://dx.doi.org/10.1080/02699052.2017.1370554"
}