@article{ref1,
title="Association of Toxoplasma gondii infection with schizophrenia and its relationship with suicide attempts in these patients",
journal="Tropical medicine and international health",
year="2017",
author="Ansari-Lari, Maryam and Farashbandi, Hassan and Mohammadi, Fahimeh",
volume="22",
number="10",
pages="1322-1327",
abstract="OBJECTIVES: To investigate the association of schizophrenia and T. gondii, and to assess the association of infection with suicide attempts and age of onset of schizophrenia in these patients. <br><br>METHODS: Case-control study Fars Province, southern Iran. Cases were individuals with psychiatric diagnosis of schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Controls were healthy blood donors, frequency matched with patients according to age and sex. For detection of IgG antibodies, enzyme-linked immunosorbent assay (ELISA) was used. Data about demographic information in all subjects and duration of illness and history of suicide attempts in schizophrenia patients were collected using a brief questionnaire and hospital records. Chi-square test and multivariable logistic regression were used for statistical analyses. <br><br>RESULTS: Among 99 cases, 42 individuals (42%) were positive for T. gondii antibody, versus 41 (27%) among 152 controls (OR=2, 95%CI: 1.2-3.4, P=0.012). We compared the suicide attempts in schizophrenia patients based on their T. gondii serologic status. There was lower rate of suicide attempts in seropositive male patients than seronegative ones (OR=0.3, 95%CI: 0.1-0.97, P=0.04). Age of onset of schizophrenia did not differ between T. gondii infected and non-infected patients. <br><br>CONCLUSIONS: These findings may have implications for schizophrenia and suicide prevention programs. However, clearly further studies are required to confirm them. This article is protected by copyright. All rights reserved.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1360-2276",
doi="10.1111/tmi.12933",
url="http://dx.doi.org/10.1111/tmi.12933"
}