@article{ref1,
title="Genetic associations and interactions between the NR3C1 (GR) and NR3C2 (MR) genes and aggressive behavior in a Central South Chinese Han Population",
journal="Genetic testing and molecular biomarkers",
year="2017",
author="Li, Jianming and Tang, Liang and Wang, Yan and Li, Fang and Bao, Meihua and Xiang, Ju and Lei, Deliang and Tang, Beisha",
volume="21",
number="8",
pages="497-505",
abstract="AIMS: The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) play important roles in hypothalamic-pituitary-adrenal axis and stress regulation. The current study aimed to address the genetic association and gene-gene interactions between GR and MR gene polymorphisms and aggressive behavior. <br><br>METHODS: A haplotype-based, case-control study was designed to examine the association between human MR and GR genes and aggressive behaviors, including robbery and intentional interpersonal injury, in a central south Chinese Han population. Eight well-studied polymorphisms of the MR gene (rs2070951, rs2871, rs5522, and rs5525) and the GR gene (rs10482605, rs6190, rs1800445, and rs6196) were genotyped using SNaPshot. <br><br>RESULTS: The MR and GR gene polymorphisms were not associated with aggressive behaviors, including in robbery and intentional interpersonal injury subgroups (p > 0.05). The frequency of haplotype TAAT of GR was significantly higher in the control group than that in the case group (p = 0.004, padj = 0.02). In addition, a two-way interaction between GR rs1800445 and MR rs2070951 and aggressive behavior was also found (p = 0.01). <br><br>CONCLUSIONS: The haplotype TAAT of GR might be a protective factor against aggressive behavior, while gene-gene interactions between GR rs1800445 and MR rs2070951 might be a risk factor for aggressive behavior in the Central South Chinese Han population.<p /> <p>Language: en</p>",
language="en",
issn="1945-0265",
doi="10.1089/gtmb.2016.0417",
url="http://dx.doi.org/10.1089/gtmb.2016.0417"
}