@article{ref1,
title="Traumatic brain injury impairs sensorimotor function in mice",
journal="Journal of surgical research",
year="2017",
author="Sackheim, Adrian M. and Stockwell, David and Villalba, Nuria and Haines, Laurel and Scott, Chary L. and Russell, Sheila and Hammack, Sayamwong E. and Freeman, Kalev",
volume="213",
number="",
pages="100-109",
abstract="INTRODUCTION: Understanding the extent to which murine models of traumatic brain injury (TBI) replicate clinically relevant neurologic outcomes is critical for mechanistic and therapeutic studies. We determined sensorimotor outcomes in a mouse model of TBI and validated the use of a standardized neurologic examination scoring system to quantify the extent of injury. <br><br>MATERIALS AND METHODS: We used a lateral fluid percussion injury model of TBI and compared TBI animals to those that underwent sham surgery. We measured neurobehavioral deficits using a standardized 12-point neurologic examination, magnetic resonance imaging, a rotating rod test, and longitudinal acoustic startle testing. <br><br>RESULTS: TBI animals had a significantly decreased ability to balance on a rotating rod and a marked reduction in the amplitude of acoustic startle response. The neurologic examination had a high inter-rater reliability (87% agreement) and correlated with latency to fall on a rotating rod (Rs = -0.809). <br><br>CONCLUSIONS: TBI impairs sensorimotor function in mice, and the extent of impairment can be predicted by a standardized neurologic examination.<br><br>Copyright © 2017 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0022-4804",
doi="10.1016/j.jss.2017.02.016",
url="http://dx.doi.org/10.1016/j.jss.2017.02.016"
}