@article{ref1,
title="Major trauma in elderly adults receiving lipid-lowering medications",
journal="Journal of trauma",
year="2001",
author="Juurlink, David N. and Sharkey, P. W. and Brenneman, Frederick D. and Naylor, C. D. and Redelmeier, D. A.",
volume="50",
number="4",
pages="678-683",
abstract="BACKGROUND: Some clinical trials, laboratory experiments, and in vitro studies suggest that lipid-lowering medications predispose a person to traumatic injury. METHODS: We used population-based administrative database analysis to study adults age 65 years or more over a 5-year interval (n = 1,348,259). RESULTS: About 12% of the cohort received a prescription for a lipid-lowering medication and about 88% did not. The two groups had similar distributions of age, gender, and income. Overall, 2,557 (0.2%) were hospitalized for major trauma. Those who received a lipid-lowering medication were 39% less likely to sustain a major trauma than those who did not receive such medication (95% confidence interval, 29 to 47). Similar results were observed after adjustment for age, gender, and income; cardiac and neurologic medications; and lethality. No other cardiac or neurologic medication was associated with an apparent safety advantage. CONCLUSION: Lipid-lowering medications do not lead to a clinically important increase in the absolute risk of major trauma for elderly patients in the community.",
language="",
issn="0022-5282",
doi="",
url="http://dx.doi.org/"
}