@article{ref1,
title="Enzymatic detection of traumatic brain injury related biomarkers",
journal="Methods in molecular biology",
year="2017",
author="Cardinell, Brittney A. and La Belle, Jeffrey T.",
volume="1572",
number="",
pages="89-112",
abstract="Electrochemical detection methods have been popular in the medical diagnostics field. Several well-known devices such as the self-monitoring blood glucose meter have relied on electrochemical techniques for their sensitivity, and ability to make direct measurements without optical labels. Currently, no point-of-care or handheld diagnostic tool exists to quantify the severity of a traumatic brain injury (TBI). We have shown that enzymatic detection of norepinephrine (NE), a biomarker which can indicate TBI severity, using impedance-based electrochemical techniques can achieve the required sensitivity, ∼100 pg/mL. Furthermore, the first steps have been taken to quantify NE in whole blood solutions and to optimize the technique for a handheld device.<p /> <p>Language: en</p>",
language="en",
issn="1064-3745",
doi="10.1007/978-1-4939-6911-1_7",
url="http://dx.doi.org/10.1007/978-1-4939-6911-1_7"
}