@article{ref1,
title="The toxicology of methadone-related death in infants under 1 year: three case series and review of the literature",
journal="Journal of forensic sciences",
year="2017",
author="Paul, Anthea B. Mahesan and Simms, Lary and Mahesan, Arnold M.",
volume="62",
number="5",
pages="1414-1417",
abstract="Methadone-related fatalities occur rarely in infants under 1 year, with five confirmed cases in the literature. The interpretation of pediatric postmortem toxicology relies on adult data; however, infants have crucial physiological differences that may impact interpretation of results. Retrospective case review included scene investigation, interviews, autopsy, and NIH/CDC Sudden Unexplained Infant Death Investigation Reporting Form. Methadone levels were confirmed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). The fatal blood methadone levels in this case series ranged from 69 to 700 ng/mL. This review of the literature adds toxicological findings of three methadone-related infant fatalities and reviews the current literature on methadone-related death in infants under 1 year. With opioid use on the rise in today's society, forensic experts should have a high index of suspicion for the possibility of intentional or unintentional poisoning in infants.<br><br>© 2017 American Academy of Forensic Sciences.<p /> <p>Language: en</p>",
language="en",
issn="0022-1198",
doi="10.1111/1556-4029.13410",
url="http://dx.doi.org/10.1111/1556-4029.13410"
}