@article{ref1,
title="Exercise interventions and prevention of fall-related fractures in older people: a meta-analysis of randomized controlled trials",
journal="International journal of epidemiology",
year="2016",
author="Zhao, Renqing and Feng, Feifei and Wang, Xinzheng",
volume="46",
number="1",
pages="149-161",
abstract="BACKGROUND: This meta-analysis aimed to determine whether exercise interventions were effective in preventing fall-related fractures in older people. The treatment effects on rate of falls, leg strength and balance were also examined. <br><br>METHODS: An electronic database search was conducted in PubMed, EMBASE, the Cochrane library and PEDro up to 1 September 2015. Randomized controlled trials (RCTs) that conducted exercise interventions and reported fall-related fracture data in older people were included. The primary outcome was the treatment effects on fall-related fractures determined by relative risk (RR) and 95% confidence interval (CI). The treatment effects on falls, leg strength and balance were also reported using rate ratio (RaR) with 95% CI and standardized mean difference (SMD) with 95% CI, respectively. Random effects models were used for meta-analysis. <br><br>RESULTS: Fifteen studies including 3136 participants met the inclusion criteria. Exercise had a beneficial effect on reduction of fall-related fractures, with pooled estimates of RR 0.604 (95% CI 0.453 - 0.840, P = 0.003, I(2 )= 0%). The rate of falls (RaR 0.856, 95% CI 0.778 - 0.941, P = 0.001, I(2 )= 45%) and leg strength (SMD 0.613, 95% CI 0.119 - 1.107, P = 0.015, I(2 )= 76.7%) were also potentially affected by exercise interventions. These only had a marginally beneficial effect on balance (SMD 0.468, 95% CI -0.011 - 0.947, P = 0.055, I(2 )= 93.6%). <br><br>CONCLUSIONS: Our findings implied that exercise interventions were effective in preventing fall-related fractures and reducing risk factors of fall-related fractures in older people.<br><br>© The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.<p /> <p>Language: en</p>",
language="en",
issn="0300-5771",
doi="10.1093/ije/dyw142",
url="http://dx.doi.org/10.1093/ije/dyw142"
}