@article{ref1,
title="Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats",
journal="Fundamental toxicological sciences",
year="2016",
author="Krishna, Acharya Bal and Manikyam, Hemanth Kumar and Sharma, Vinay K. and Sharma, Niti",
volume="3",
number="1",
pages="9-12",
abstract="Picrorhiza kurroa is a well-known ayurvedic or herbal medicine which is used very commonly in the treatment of various diseases. Therefore, we studied the oral toxicity of Picrorhiza kurroa rhizome extract in rats. A single high dose of the extract at 2000 mg/kg body weight was tested on Wistar rats. Mortality/viability and clinical signs were recorded on test day 0 (prior to administration), 7, 14 and at death. All animals appeared normal from day one to throughout the experimental procedure. Picrorhiza kurroa rhizome extract is non-toxic to rats and helped in weight gain with LD50 > 2000 mg/kg body weight. Oral administration of Picrorhiza kurroa is not connected with any toxicologically significant effects and the data could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.<p /> <p>Language: en</p>",
language="en",
issn="2189-115X",
doi="10.2131/fts.3.9",
url="http://dx.doi.org/10.2131/fts.3.9"
}