@article{ref1,
title="Correlation between expression of peripheral IL-17 protein and aggression of bipolar mania",
journal="Fa Yi Xue Za Zhi",
year="2016",
author="Li, Hao-zhe and Hong, Wu and Wang, Zuo-wei and Yuan, Cheng-mei and Li, Ze-zhi and Huang, Jia and Zhang, Chen and Li, Ning-ning and Lin, Zhi-guang and Fang, Yi-Ru",
volume="32",
number="1",
pages="40-44",
abstract="OBJECTIVE: To explore the correlation between the interleukin-17 (IL-17) level of peripheral blood and aggression of bipolar mania. <br><br>METHODS: Thirty-six patients of bipolar mania were selected as experimental group by DSM-IV-TR and received treatment with quetiapine and lithium. Thirty-six healthy volunteers with similar age and gender were selected as control group. The level of IL-17 at baseline in each group and the level of IL-17 in the experimental group after treatment for 2, 4 and 8 weeks were detected by ELISA. <br><br>RESULTS: The level of IL-17 in experimental group at baseline, after treatment for 2 and 4 weeks were all significantly higher than that in control group. After 8 weeks treatment, there was no significant difference between the two groups (P > 0.05). After 2, 4 and 8 weeks treatment, the total score and aggression score of Young Mania Rating Score (YMRS) were significantly lower than the baseline level (P < 0.05). In experimental group, the level of IL-17 was positively correlated with the two scores of YMRS at baseline (P < 0.05). <br><br>CONCLUSION: Bipolar mania may be related to the up-regulation of IL-17. The level of IL-17 is related to the severity of manic symptoms at baseline, especially aggression symptom.<p /> <p>Language: zh</p>",
language="zh",
issn="1004-5619",
doi="",
url="http://dx.doi.org/"
}