@article{ref1,
title="Over-the-counter drug induced autoimmune hepatitis",
journal="Internal medicine",
year="2016",
author="Takeda, Karin and Oda, Masaya and Okada, Takemichi and Yamazaki, Hitoshi and Ohbu, Makoto and Watanabe, Masaaki and Yokomori, Hiroaki",
volume="55",
number="10",
pages="1293-1297",
abstract="A 64-year-old man seeking treatment for a common cold was admitted to our hospital due to symptoms of general fatigue and liver dysfunction. A thorough history review revealed that the patient had recently started taking an over-the-counter (OTC) drug. Drug-induced lymphocyte stimulation tests were positive. Serum markers for autoimmune hepatitis (AIH) were particularly elevated. Liver biopsy revealed spotty necrosis and ceroid-pigmented Kupffer cells and piecemeal necrosis with multiple plasma cells. He responded to corticosteroids, thus suggesting the presence of an immune-mediated component associated with the liver injury. Liver injury after using OTCs should be included in the differential diagnosis for chronic hepatitis with features of AIH.<p /> <p>Language: en</p>",
language="en",
issn="0918-2918",
doi="10.2169/internalmedicine.55.5509",
url="http://dx.doi.org/10.2169/internalmedicine.55.5509"
}