@article{ref1,
title="The identification, metabolism and toxicity of an unknown component found in a new clandestine drug tablet",
journal="Japanese journal of forensic science and technology",
year="2010",
author="Kamata, Hiroe and Katagi, Munehiro and Miki, Akihiro and Nishikawa, Mayumi and Tsuchihashi, Hitoshi",
volume="15",
number="2",
pages="75-84",
abstract="In 2006, brownish-pink clandestine tablets with an &quot;S&quot; stamp mark were seized in several prefectures in Japan. These were reportedly sold as &quot;Ecstasy (MDMA tablet)&quot;, but routine analysis indicated no traces of any controlled substances or common recreational drugs. However, additional high resolution mass spectrometry and nuclear magnetic resonance spectroscopy confirmed the unusual component N-(2,4,6-trimethylphenyl)phthalimide (TMPPI). Because this compound is considered to be a derivative of Thalidomide, potential sedative and anticarcinogenic effects were expected from its structure.   To investigate its metabolism and toxicity, administration experiments were conducted on rats. As a result, N-(o-carboxybenzoyl)-2,4,6-trimethylaniline was identified as a specific metabolite in the rats' urine. Furthermore, no symptoms were noticed with a single dose of 350 mg/kg TMPPI. Thus, TMPPI was found to have a low acute toxicity.<p />",
language="ja",
issn="1880-1323",
doi="10.3408/jafst.15.75",
url="http://dx.doi.org/10.3408/jafst.15.75"
}