@article{ref1,
title="Illness history: not associated with remission during treatment of major depression in 515 mood disorder patients",
journal="Journal of affective disorders",
year="2015",
author="Baldessarini, Ross J. and Tondo, Leonardo and Visioli, Caterina and Vazquez, Gustavo H.",
volume="191",
number="",
pages="118-122",
abstract="BACKGROUND: There is suggestive evidence that prior illness history may have little association with response to long-term treatment in bipolar disorder (BD) or recurrent major depressive disorder (MDD), but relationships of illness-history to treatment-response in acute episodes of depression require further testing. <br><br>METHODS: We tested for associations of selected measures of illness history with remission during treatment of an acute index episode of major depression in 515 mood-disorder patients (327 MDD, 188 BD), using bivariate and multivariate methods. <br><br>RESULTS: Remission of depression was more likely with lesser initial symptom-severity and bipolar diagnosis, but not related to years since illness-onset, previous depressions or episodes (based on counts, yearly rates, or %-of months ill), or other indices of illness-severity (hospitalization, co-morbidity, suicide attempt). <br><br>CONCLUSIONS: Likelihood of response to standard treatments for acute major depressive episodes in MDD or BD appeared to be largely independent of prior illness-history.<p /> <p>Language: en</p>",
language="en",
issn="0165-0327",
doi="10.1016/j.jad.2015.10.058",
url="http://dx.doi.org/10.1016/j.jad.2015.10.058"
}