@article{ref1,
title="Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case-control study",
journal="British journal of obstetrics and gynaecology: BJOG",
year="2015",
author="Vikström, J. and Sydsjö, G. and Hammar, M. and Bladh, M. and Josefsson, A.",
volume="124",
number="3",
pages="435-442",
abstract="OBJECTIVE: To examine whether women who undergo in vitro fertilisation (IVF) treatment are at greater risk of postnatal suicide or postnatal depression (PND) requiring psychiatric care, compared with women who conceive spontaneously. <br><br>DESIGN: Case-control study using data from national registers. SETTING: Sweden during the period 2003-2009. POPULATION: Cases were 3532 primiparous women who had given birth following IVF treatment. An aged-matched control group of 8553 mothers was randomly selected from the medical birth register. <br><br>METHODS: Logistic regression analyses were performed with PND as the outcome, and with known risk factors of PND as well as IVF/spontaneous birth as covariates. MAIN OUTCOME MEASURES: Postnatal depression (PND), defined as diagnoses F32-F39 of the tenth edition of the International Classification of Diseases (ICD-10), within 12 months of childbirth. <br><br>RESULTS: Initial analyses showed that PND was more common in the control group than in the IVF group (0.8 versus 0.4%; P = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (P = 0.000; odds ratio, OR = 25.5; 95% confidence interval, 95% CI = 11.7-55.5), any previous affective disorder (P = 0.000; OR = 26.0; 95% CI = 10.5-64.0), or specifically a personality disorder (P = 0.028; OR = 3.8; 95% CI = 1.2-12.7) increased the risk of PND. No woman in either group committed suicide during the first year after childbirth. <br><br>CONCLUSIONS: Whereas mothers who receive IVF treatment are not at increased risk of PND, the risk is increased among mothers with a history of mental illness. TWEETABLE ABSTRACT: A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.<p /> <p>Language: en</p>",
language="en",
issn="1470-0328",
doi="10.1111/1471-0528.13788",
url="http://dx.doi.org/10.1111/1471-0528.13788"
}