@article{ref1,
title="Curare alkaloids: constituents of a Matis dart poison",
journal="Journal of natural products",
year="2015",
author="Malca Garcia, Gonzalo R. and Hennig, Lothar and Shelukhina, Irina V. and Kudryavtsev, Denis S. and Bussmann, Rainer W. and Tsetlin, Victor I. and Giannis, Athanassios",
volume="78",
number="11",
pages="2537-2544",
abstract="A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of d-(-)-quinic acid, l-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. d-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.<p /> <p>Language: en</p>",
language="en",
issn="0163-3864",
doi="10.1021/acs.jnatprod.5b00457",
url="http://dx.doi.org/10.1021/acs.jnatprod.5b00457"
}