@article{ref1,
title="Change in motor and nonmotor symptoms severity in a "real-life" cohort of subjects with Parkinson's disease",
journal="Neurosci J",
year="2015",
author="Jorge de Saráchaga, Adib and Cervantes-Arriaga, Amin and Llorens-Arenas, Rodrigo and Calderón-Fajardo, Humberto and Rodríguez-Violante, Mayela",
volume="2015",
number="",
pages="e368989-e368989",
abstract="Background. Parkinson's disease (PD) is a chronic and progressive disorder. Rates of change in motor symptoms have been more studied compared to nonmotor symptoms. The objective was to describe these changes in a real-life cohort of subjects with PD. <br><br>METHODS. A cohort study was carried out from 2011 to 2013. Consecutive patients with PD were recruited from a movement disorders clinic. MDS-UPDRS, PDQ-8, and NMSS were applied to all subjects at an initial evaluation and a subsequent visit (21 ± 3 months). Disease severity was categorized using a recent classification of MDS-UPDRS severity. <br><br>RESULTS. The MDS-UPDRS Part III showed a significant decrease of 7.2 ± 2.31 points (p = 0.001) between evaluations. A mean increase of 0.9 ± 0.6 points (p = 0.015) in the MDS-UPDRS Part IV was observed. An increase of 14.3 ± 11.4 points (p = 0.043) in the NMSS total score was found; when assessed individually, the difference was statistically significant only for the perceptual problems/hallucinations item. Quality of life remained unchanged. <br><br>CONCLUSION. Motor improvement was observed accompanied by an increase in motor complications possibly as a result of treatment optimization. Nonmotor symptoms worsened as a whole. The overall effect in the quality of life was negligible.<p /> <p>Language: en</p>",
language="en",
issn="2314-4262",
doi="10.1155/2015/368989",
url="http://dx.doi.org/10.1155/2015/368989"
}