@article{ref1,
title="Pupillary responses to light in chronic non-blast-induced mTBI",
journal="Brain injury",
year="2015",
author="Thiagarajan, Preethi and Ciuffreda, Kenneth J.",
volume="29",
number="12",
pages="1420-1425",
abstract="PURPOSE: To evaluate objectively and quantitatively human pupillary responses to a light stimulus under photopic conditions in individuals with non-blast-induced, chronic, mild traumatic brain injury (mTBI). <br><br>METHODS: Seventeen individuals with chronic, non-blast-induced mTBI and 15 visually-normal (VN) controls were tested (aged 21-45 years). Pupillary responsivity to a brief step-input light stimulus was assessed objectively in each eye for 5 seconds using the Neuroptics PLR-200 monocular, hand-held pupillometer with its pre-set and automated eight parameter analysis. <br><br>RESULTS: Five of the eight parameters assessed were significantly reduced (p ≤ 0.05) in the mTBI group as compared to the VN control group: maximum (or peak) constriction velocity, average constriction velocity, average dilation velocity, maximum diameter and amplitude of constriction. The remaining three parameters were similar in each group (p > 0.05): constriction latency, 75% dilation recovery time and minimum diameter. <br><br>CONCLUSIONS: The slowed dilation dynamics and reduced maximum pupillary diameter in mTBI suggest deficiency primarily of the sympathetic control system. The reduced peak velocities and related amplitudes suggest subtle parasympathetic involvement.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.3109/02699052.2015.1045029",
url="http://dx.doi.org/10.3109/02699052.2015.1045029"
}