@article{ref1,
title="Anti-dementia drugs-related changes in gait performance while single and dual tasking in patients with Alzheimer disease: a meta-analysis",
journal="Current Alzheimer research",
year="2015",
author="Beauchet, O. and Cp, Launay and Montero-Odasso, M. and Annweiler, C. and Allali, V.",
volume="12",
number="8",
pages="761-771",
abstract="BACKGROUND: The effects of anti-dementia drugs on gait performance in Alzheimer disease (AD) are questionable. The objective of this meta-analysis was to examine the effects of anti-dementia drugs on the mean value and the coefficient of variation (CoV) of stride time among patients with AD while taking into account the type of drugs (i.e., acetylcholinesterase inhibitors [AChEIs] versus memantine) and the walking conditions (i.e., single versus dual-task). <br><br>METHODS: An English and French Medline search was conducted in March 2015, with no limit of date, using the Medical Subject Headings terms &quot;pharmaceutical preparations&quot; combined with terms &quot;Pharmaceutical preparations&quot; OR &quot;Therapeutic uses&quot; OR &quot;Drug substitution&quot; OR &quot;Drugs essential&quot; OR &quot;Drugs, Generic&quot; OR &quot;Psychotropic drugs&quot; combined with &quot;Delirium&quot; OR &quot;Dementia&quot; OR &quot;Amnestic&quot; OR &quot;Cognitive disorders&quot; AND &quot;Gait&quot; OR &quot;Gait Ataxia&quot; OR &quot;Gait disorders, Neurologic&quot; OR &quot;Gait apraxia&quot;. Fixed-effects meta-analyses were used to examine anti-dementia drugs-related changes in mean value and CoV of stride time. <br><br>RESULTS: Of the 66 identified abstracts, 5 (7.6%) were included in the meta-analysis. Inter-group comparison of between-visit change underscored a significant decrease in CoV of stride time (P<0.004) in intervention group compared to control group, whatever the pooled analysis considered, but no significant change in the mean value (P>0.06). Intra-group changes in stride time parameters following the use of anti-dementia drugs showed a significant decrease for memantine (P<0.001) and while pooling AChEIs and memantine (P<0.001) under single task condition. Under dual task condition, only AChEIs improved significantly stride time parameters (P=0.002). <br><br>CONCLUSIONS: Anti-dementia drugs demonstrated a significant improvement of gait performance with specific class effect depending on the walking conditions and on the type of stride time parameters considered.<p /> <p>Language: en</p>",
language="en",
issn="1567-2050",
doi="",
url="http://dx.doi.org/"
}