@article{ref1,
title="The association between obstructive sleep apnea and metabolic markers and lipid profiles",
journal="PLoS one",
year="2015",
author="Wu, Wei-Te and Tsai, Su-Shan and Shih, Tung-Sheng and Lin, Ming-Hsiu and Chou, Tzu-Chieh and Ting, Hua and Wu, Trong-Neng and Liou, Saou-Hsing",
volume="10",
number="6",
pages="e0130279-e0130279",
abstract="PURPOSE: The purpose of this study was to investigate the association between apnea-hypopnea index (AHI) and metabolic markers and whether the elevated risk of Metabolic Syndrome (MetS) is related to Obstructive Sleep Apnea (OSA). <br><br>METHODS: This cross-sectional study recruited 246 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test and by blood lipids examination. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). <br><br>RESULTS: The results showed that a 73.3% prevalence of MetS in OSA (AHI > 15) and a 80.0% prevalence of MetS in severe OSA (AHI > 30) were found. After adjusting for confounding variables, an increased level of Body-Mass Index (BMI) and two non-MetS cardiovascular risk factors, total cholesterol/HDL-C ratio and TG/HDL-C ratio was significantly associated with AHI in subjects with severe OSA. MetS was about three times to be present in subjects with severe OSA, even adjusted for BMI. <br><br>CONCLUSIONS: The findings showed a high prevalence of MetS in OSA among professional drivers, especially in the severe group category. BMI was the major contributing factor to OSA. However, the present study did not find a sensitive clinical marker of a detrimental metabolic profile in OSA patients.<p /> <p>Language: en</p>",
language="en",
issn="1932-6203",
doi="10.1371/journal.pone.0130279",
url="http://dx.doi.org/10.1371/journal.pone.0130279"
}