@article{ref1,
title="Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators",
journal="Structure",
year="2015",
author="Undheim, Eivind A. B. and Grimm, Lena L. and Low, Chek-Fong and Morgenstern, David and Herzig, Volker and Zobel-Thropp, Pamela and Pineda, Sandy Steffany and Habib, Rosaline and Dziemborowicz, Slawomir and Fry, Bryan G. and Nicholson, Graham M. and Binford, Greta J. and Mobli, Mehdi and King, Glenn F.",
volume="23",
number="7",
pages="1283-1292",
abstract="Arthropod venoms consist primarily of peptide toxins that are injected into their prey with devastating consequences. Venom proteins are thought to be recruited from endogenous body proteins and mutated to yield neofunctionalized toxins with remarkable affinity for specific subtypes of ion channels and receptors. However, the evolutionary history of venom peptides remains poorly understood. Here we show that a neuropeptide hormone has been convergently recruited into the venom of spiders and centipedes and evolved into a highly stable toxin through divergent modification of the ancestral gene. High-resolution structures of representative hormone-derived toxins revealed they possess a unique structure and disulfide framework and that the key structural adaptation in weaponization of the ancestral hormone was loss of a C-terminal α helix, an adaptation that occurred independently in spiders and centipedes. Our results raise a new paradigm for toxin evolution and highlight the value of structural information in providing insight into protein evolution.<p /> <p>Language: en</p>",
language="en",
issn="0969-2126",
doi="10.1016/j.str.2015.05.003",
url="http://dx.doi.org/10.1016/j.str.2015.05.003"
}