@article{ref1,
title="MAO a and MAO B in suicidal behavior",
journal="Psychiatria Danubina",
year="2006",
author="Giegling, Ina and Hartmann, Annette M. and Moller, Hans-Jurgen and Rujescu, Dan",
volume="18",
number="Suppl 1",
pages="74-74",
abstract="Risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, traumatic life experiences, psychiatric history, personality traits, and genetic vulnerability. Family and twin studies point towards a partial heritability of suicidal behavior and aggression-related traits. We have initiated a large scale case control genetic association study which comprises of 250 suicide attempters and 1600 healthy volunteers and investigated the role of a comprehensive set of candidate genes in this behavior. We will present new data on the MAO A and MAO B genes as candidate genes for these traits. We studied several gene variants of MAO A and MAO B in a sample of 571 suicide attempters, healthy controls and suicide completers. We also analyzed the relation to aggression-related traits, assessed by STAXI and FAF. Our results provide evidence that the MAO A and MOA B may influence aggression-related traits. Given that these represent intermediate phenotypes of suicidal behavior, MAO A and MAO B might also act on suicidal behavior through these traits. The observed associations warrant further replications.<p /> <p>Language: en</p>",
language="en",
issn="0353-5053",
doi="",
url="http://dx.doi.org/"
}