@article{ref1,
title="The juvenile head trauma syndrome: a trauma triggered migraine?",
journal="Neuropediatrics",
year="2015",
author="van der Veek, Emma M. J. and Oosterhoff, Matthijs and Vos, Pieter E. and Hageman, Gerard",
volume="46",
number="2",
pages="116-122",
abstract="Background The underlying mechanism of the juvenile head trauma syndrome (JHTS) is still uncertain, but it has been suggested that there is a role in cortical spreading depression, a phenomenon that is assumed to be a part of the pathophysiology of migraine. Hypothesis We postulate that children affected by the JHTS are more susceptible to cortical spreading depression, caused by a genetic etiology similar to genetic factors in migraine. <br><br>METHODS Children with the JHTS were selected and evaluated retrospectively in an observational case-control study in two Dutch trauma centers in the period between January 2008 and July 2012. <br><br>RESULTS We included 33 patients with the JHTS, who were accounted for approximately 2.5% of the total number (1,342) of children seen at the emergency department with a mild head trauma. The prevalence of migraine in cases compared with controls did not differ. The proportion of patients with a first-degree relative with migraine was significantly higher in cases compared with controls (odds ratio, 2.69; 95% confidence interval, 1.16-6.22; p = 0.010). <br><br>CONCLUSION The JHTS is a relatively rare phenomenon, seen in approximately 2.5% of all children seen at the emergency department with mild brain injury. This study demonstrates a significant relationship between the JHTS and a positive history of migraine in first-degree relatives.<p /> <p>Language: en</p>",
language="en",
issn="0174-304X",
doi="10.1055/s-0035-1547344",
url="http://dx.doi.org/10.1055/s-0035-1547344"
}