@article{ref1,
title="Fatal mechanical asphyxia induces changes in energy utilization in the rat brain: an (18)F-FDG-PET study",
journal="Legal medicine (Elsevier)",
year="2015",
author="Ma, Suhua and You, Shengzhong and Hao, Li and Zhang, Dongchuan and Quan, Linda",
volume="17",
number="4",
pages="239-244",
abstract="PURPOSE: This study was designed to evaluate changes in brain glucose metabolism in rats following ligature strangulation. <br><br>MATERIALS AND METHODS: Thirteen male Wistar rats were used in the present study, divided into control (n=7) and asphyxia groups (n=6, ligature strangulation). Positron emission tomography (PET) with 2-deoxy-2-[(18)F]fluoro-d-glucose ((18)F-FDG) was used to evaluate brain glucose metabolism. Rats were scanned for PET-CT, and image data co-registered with a T2WI MRI template using SPM8 software. Image J was employed to draw regions of interest (ROIs) from the MRI template and acquire ROI activity information from the PET images. <br><br>RESULTS: In the asphyxia group vs. controls, (18)F-FDG uptake (FU) was decreased in the substantia nigra (25.26%, p<0.001), rhombencephalon (pons/medulla oblongata, 13.92%, p<0.01), hypothalamus (22.06%, p<0.01), ventral tegmentum (10.12%, p<0.05) and amygdala (12.74%, p<0.05); however, FU was increased in motor (18.21%, p<0.05) and visual cortices (19.2%, p<0.05). <br><br>CONCLUSIONS: The glucose metabolism distribution map in the asphyxiated rat brains were substantially changed versus controls. PET with (18)F-FDG can demonstrate excitement and inhibition of different brain areas even in cases of ligature strangulation.<p /> <p>Language: en</p>",
language="en",
issn="1344-6223",
doi="10.1016/j.legalmed.2015.02.002",
url="http://dx.doi.org/10.1016/j.legalmed.2015.02.002"
}