@article{ref1,
title="Combining Seeking Safety with sertraline for PTSD and alcohol use disorders: a randomized controlled trial",
journal="Journal of consulting and clinical psychology",
year="2015",
author="Hien, Denise A. and Levin, Frances Rudnick and Ruglass, Lesia M. and López-Castro, Teresa and Papini, Santiago and Hu, Mei-Chen and Cohen, Lisa Renee and Herron, Abigail",
volume="83",
number="2",
pages="359-369",
abstract="OBJECTIVE: The current study marks the first randomized controlled trial to test the benefit of combining Seeking Safety (SS), a present-focused cognitive-behavioral therapy for co-occurring posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD), with sertraline, a front-line medication for PTSD shown to also impact drinking outcomes. <br><br>METHOD: Sixty-nine participants (81% female; 59% African American) with primarily childhood sexual (46%) and physical (39%) trauma exposure, and drug dependence in addition to AUD were randomized to receive a partial-dose (12 sessions) of SS with either sertraline (n = 32; M = 7 sessions) or placebo (n = 37; M = 6 sessions). Assessments conducted at baseline, end-of-treatment, 6- and 12-months posttreatment measured PTSD and AUD symptom severity. <br><br>RESULTS: Both groups demonstrated significant improvement in PTSD symptoms. The SS plus sertraline group exhibited a significantly greater reduction in PTSD symptoms than the SS plus placebo group at end-of-treatment (M difference = -16.15, p =.04, d = 0.83), which was sustained at 6- and 12-month follow-up (M difference = -13.81, p =.04, d = 0.71, and M difference = -12.72, p =.05, d = 0.65, respectively). Both SS groups improved significantly on AUD severity at all posttreatment time points with no significant differences between SS plus sertraline and SS plus placebo. <br><br>CONCLUSION: Results support the combining of a cognitive-behavioral therapy and sertraline for PTSD/AUD. Clinically significant reductions in both PTSD and AUD severity were achieved and sustained through 12-months follow-up, Moreover, greater mean improvement in PTSD symptoms was observed across all follow-up assessments in the SS plus sertraline group. (PsycINFO Database Record (c) 2015 APA, all rights reserved).<p /> <p>Language: en</p>",
language="en",
issn="0022-006X",
doi="10.1037/a0038719",
url="http://dx.doi.org/10.1037/a0038719"
}