@article{ref1,
title="Community-dwelling female fallers have lower muscle density in their lower legs than non-fallers: evidence from the Saskatoon Canadian Multicentre Osteoporosis Study (CaMos) cohort",
journal="Journal of nutrition, health, and aging",
year="2015",
author="Frank, A. W. and Farthing, J. P. and Chilibeck, P. D. and Arnold, C. M. and Olszynski, W. P. and Kontulainen, S. A.",
volume="19",
number="1",
pages="113-120",
abstract="OBJECTIVES: Our objectives were to determine whether peripheral quantitative computed tomography (pQCT)-derived lower leg muscle density and area, and basic functional mobility differ between community-dwelling older women who do and do not report recent falls. <br><br>DESIGN: Matched case-control comparison. SETTING: Academic biomedical imaging laboratory. PARTICIPANTS: 147 Women, 60 years or older (mean age 74.3 y, SD 7.7) recruited from a longitudinal, population-based cohort representing community-dwelling residents in the area of Saskatoon, Canada. MEASUREMENTS: A cross-sectional pQCT scan of the non-dominant lower leg was acquired to determine muscle density and area. Basic functional mobility (Timed Up and Go Test [TUG]) and SF36 health status were also measured. Fallers (one or more falls) and non-fallers (no falls) were grouped according to a 12-month retrospective survey and matched on measured covariates. <br><br>RESULTS: The muscle density of fallers (n = 35) was a median of 2.1 mg/cm3 lower (P = 0.019, 95% C.I. -3.9 to -0.1) than non-fallers (n = 78) after matching and adjusting for age, body mass index, and SF36 general health scores. Muscle area and TUG did not differ between fallers and non-fallers. <br><br>CONCLUSIONS: Muscle density may serve as a physiological marker in the assessment of lower leg muscular health and fall risk in community-dwelling elderly women. These results are limited to our study population who were mostly Caucasian. Prospective studies are required for verification.<p /> <p>Language: en</p>",
language="en",
issn="1279-7707",
doi="10.1007/s12603-014-0476-6",
url="http://dx.doi.org/10.1007/s12603-014-0476-6"
}