@article{ref1,
title="The neurobiology of suicide",
journal="Lancet psychiatry",
year="2014",
author="van Heeringen, Cornelis Kees and Mann, J. John",
volume="1",
number="1",
pages="63-72",
abstract="The stress-diathesis model posits that suicide is the result of an interaction between state-dependent (environmental) stressors and a trait-like diathesis or susceptibility to suicidal behaviour, independent of psychiatric disorders. <br><br>FINDINGS from post-mortem studies of the brain and from genomic and in-vivo neuroimaging studies indicate a biological basis for this diathesis, indicating the importance of neurobiological screening and interventions, in addition to cognitive and mood interventions, in the prevention of suicide. Early-life adversity and epigenetic mechanisms might explain some of the link between suicide risk and brain circuitry and neurochemistry abnormalities. <br><br>RESULTS from a range of studies using diverse designs and post-mortem and in-vivo techniques show impairments of the serotonin neurotransmitter system and the hypothalamic-pituitary-adrenal axis stress-response system in the diathesis for suicidal behaviour. These impairments manifest as impaired cognitive control of mood, pessimism, reactive aggressive traits, impaired problem solving, over-reactivity to negative social signs, excessive emotional pain, and suicidal ideation, leading to suicidal behaviour. Biomarkers related to the diathesis might help to inform risk-assessment procedures and treatment choice in the prevention of suicide.<p /> <p>Language: en</p>",
language="en",
issn="2215-0374",
doi="10.1016/S2215-0366(14)70220-2",
url="http://dx.doi.org/10.1016/S2215-0366(14)70220-2"
}