@article{ref1,
title="Three time point changes in diffusion tensor values and their association with cognitive sequel among mild injury patients",
journal="Journal of neurosurgical sciences",
year="2014",
author="Munivenkatappa, A. and Devi, B. I. and Shukla, D. P. and Rajeswaran, J.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="AIM: Diffusion tensor imaging (DTI) is an advanced and sensitive technique that detects sub--threshold pathology in normal imaging brain injury patients. Currently, there are no 3time--point studies that have considered DTI technique among these patients. The present study has investigated 3time--point DTI imaging and its association with cognitive deficits. <br><br>METHODS: Twenty--one patients were available for MRI and neuropsychological test (NPT) assessment for all the 3time-points. Initially (<36hours), all patients presented with GCS 15 and normal scan findings. The DTI (p<0.0001) and NPT scores (p<0.05) were analyzed using repeated--measure of analysis. The tensor values were correlated with specific time--point NPT scores using partial correlation (0.05). <br><br>RESULTS: Right cerebral--hemisphere showed significant alterations in both anisotropy and diffusivity values overtime. Cingulate--gyrus and occipital--lobe showed prominent changes in anisotropy value. Significant improvement in thalamo--cortical anisotropy value after 3--4months after injury was seen. The changes in diffusivity values were majorly seen in frontal, parietal lobe, right inferior fronto--occipital & superior longitudinal fasciculus, and posterior supramarginal gyrus. Eventual changes of tensor values of thalamus, frontal and temporal lobe had persistent and significant association with attention and learning/memory aspects. <br><br>CONCLUSION: The study's findings suggest that DTI detects and observes natural--recovery of brain regions affected by sub--threshold force.<p /><p>Language: en</p>",
language="en",
issn="0390-5616",
doi="",
url="http://dx.doi.org/"
}