@article{ref1,
title="Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex- specific effects",
journal="Behavioural brain research",
year="2014",
author="Shanks, Ryan A. and Ross, Jordan M. and Doyle, Hillary H. and Helton, Amanda K. and Picou, Brittany D. and Schulz, Jordyn and Tavares, Chris and Bryant, Sarah and Dawson, Bryan L. and Lloyd, Steven A.",
volume="281",
number="",
pages="116-124",
abstract="The increasing availability, over-prescription, and misuse and abuse of ADHD psychostimulant medications in adolescent populations necessitates studies investigating the long-term effects of these drugs persisting into adulthood. Male and female C57Bl/6J mice were exposed to amphetamine (AMPH) (1.0 and 10mg/kg), methylphenidate (MPD) (1.0 and 10mg/kg), or cocaine (COC) (5.0mg/kg) from postnatal day 22 to 31, which represents an early adolescent period. After an extended period of drug abstinence, adult mice were challenged with a subacute methamphetamine (METH) dose (0.5mg/kg), to test the long-term effects of adolescent drug exposures on behavioral cross-sensitization using an open field chamber. There were no sex- or dose-specific effects on motor activity in adolescent, saline-treated controls. However, AMPH, MPD, and COC adolescent exposures induced cross-sensitization to a subacute METH dose in adulthood, which is a hallmark of addiction and a marker of long-lasting plastic changes in the brain. Of additional clinical importance, AMPH-exposed male mice demonstrated increased cross-sensitization to METH in contrast to the female-specific response observed in MPD-treated animals. There were no sex-specific effects after adolescent COC exposures. This study demonstrates differential drug, dose, and sex-specific alterations induced by early adolescent psychostimulant exposure, which leads to behavioral alterations that persist into adulthood.<p /> <p>Language: en</p>",
language="en",
issn="0166-4328",
doi="10.1016/j.bbr.2014.12.002",
url="http://dx.doi.org/10.1016/j.bbr.2014.12.002"
}