@article{ref1,
title="A dose-response model incorporating nonlinear kinetics",
journal="Biometrics",
year="1987",
author="Van Ryzin, J. and Rai, K.",
volume="43",
number="1",
pages="95-105",
abstract="This paper introduces a dose-response model for toxic quantal response data based on hit theory applied to the dose unit as transformed by a nonlinear kinetic equation. When spontaneous background response is included in the model, the resulting dose-response model has four parameters. The maximum likelihood estimators and their large-sample properties are given. Likelihood ratio tests of interest are developed, including one for whether the model is one-hit in the transformed dose and one to check whether nonlinear kinetics is operative. The use of the model for low-dose extrapolation is presented. Finally, the procedures developed are illustrated on data from three animal carcinogenicity bioassays that show, respectively, concave, linear, and convex dose-response curves in the observed data.<p /><p>Language: en</p>",
language="en",
issn="0006-341X",
doi="",
url="http://dx.doi.org/"
}