@article{ref1,
title="Fatal hepatic necrosis due to pyrimethamine-sulfadoxine (Fansidar)",
journal="Annals of internal medicine",
year="1987",
author="Zitelli, B. J. and Alexander, W. Robert J. and Taylor, S. and Miller, K. D. and Howrie, D. L. and Kuritsky, J. N. and Perez, T. H. and Van Thiel, D. H.",
volume="106",
number="3",
pages="393-395",
abstract="Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.<p /><p>Language: en</p>",
language="en",
issn="0003-4819",
doi="",
url="http://dx.doi.org/"
}