@article{ref1,
title="Effect of 6-OHDA injected into the locus coeruleus on apomorphine-induced aggression",
journal="Pharmacology, biochemistry, and behavior",
year="1986",
author="Puciłowski, O. and Kozak, W. and Valzelli, L.",
volume="24",
number="3",
pages="773-775",
abstract="Bilateral microinjections of 6-hydroxydopamine (6-OHDA) into the nuclei loci coerulei (LC) of male Wistar rats resulted in significant depletion of mesencephalic and striatal norepinephrine, accompanied by a small reduction in dopamine content only in the striatum. Apomorphine (2.5 mg/kg IP) induced marked aggression consisting of prolonged posturing, vocalization and attacks only in 6-OHDA lesioned animals. Biochemical analysis revealed that 6-OHDA antagonized the ability of apomorphine to raise the serotonin concentration in the striatum. It is concluded that the LC neurons play an inhibitory role in apomorphine-induced aggressiveness and the involvement of serotonergic neurons is suggested.<p /><p>Language: en</p>",
language="en",
issn="0091-3057",
doi="",
url="http://dx.doi.org/"
}