@article{ref1,
title="HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides",
journal="Human and experimental toxicology",
year="1991",
author="Kusić, R. and Jovanovic, D. and Randjelović, S. and Joksović, D. and Todorovic, V. and Bosković, B. and Jokanovic, M. and Vojvodić, V.",
volume="10",
number="2",
pages="113-118",
abstract="The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d. HI-6 rapidly reactivated human blood acetylcholinesterase inhibited by dimethoxy organophosphorus compounds, while the dimethoxy-inhibited enzyme was mainly resistant to the treatment by HI-6. Although both HI-6 and pralidoxime chloride reactivated the red blood cell cholinesterase in quinalphos-poisoned subjects, the return of enzyme activities was more rapid following the use of HI-6. The general improvement of poisoned patients, which was sometimes more rapid than the rise of acetylcholinesterase activity, pointed to direct pharmacological effects of HI-6. No undesirable side-effects were noted in patients when HI-6 plasma concentrations were maintained at levels far above the 'therapeutic' concentration for up to 7 d.<p /><p>Language: en</p>",
language="en",
issn="0960-3271",
doi="",
url="http://dx.doi.org/"
}