@article{ref1,
title="Prediction of post-earthquake depressive and anxiety symptoms: a longitudinal resting-state fMRI study",
journal="Scientific reports",
year="2014",
author="Long, Jinyi and Huang, Xiaoqi and Liao, Yi and Hu, Xinyu and Hu, Junmei and Lui, Su and Zhang, Rui and Li, Yuanqing and Gong, Qiyong",
volume="4",
number="",
pages="6423-6423",
abstract="Neurobiological markers of stress symptom progression for healthy survivors from a disaster (e.g., an earthquake) would greatly help with early intervention to prevent the development of stress-related disorders. However, the relationship between the neurobiological alterations and the symptom progression over time is unclear. Here, we examined 44 healthy survivors of the Wenchuan earthquake in China in a longitudinal resting-state fMRI study to observe the alterations of brain functions related to depressive or anxiety symptom progression. Using multi-variate pattern analysis to the fMRI data, we successfully predicted the depressive or anxiety symptom severity for these survivors in short- (25 days) and long-term (2 years) and the symptom severity changes over time. Several brain areas (e.g., the frontolimbic and striatal areas) and the functional connectivities located within the fronto-striato-thalamic and default-mode networks were found to be correlated with the symptom progression and might play important roles in the adaptation to trauma.<p /> <p>Language: en</p>",
language="en",
issn="2045-2322",
doi="10.1038/srep06423",
url="http://dx.doi.org/10.1038/srep06423"
}