@article{ref1,
title="Cardiovascular, metabolic and neurologic effects of acute carbon monoxide poisoning in the rat",
journal="Toxicology letters",
year="1989",
author="Penney, D. G. and Verma, K. and Hull, J. A.",
volume="45",
number="2-3",
pages="207-213",
abstract="Acute severe carbon monoxide poisoning was investigated in a modified Levine preparation. The rats inhaled 2700 p.p.m. CO for 90 min (COHb = 80%). Body temperature, heart rate and carotid systemic and 'stump' blood pressure declined sharply during CO exposure. By 2 and 4 h post-CO, body temperature and blood pressure had not renormalized, while heart rate was elevated. Blood glucose was unchanged at termination of CO exposure, but increased from 115 mg/dl to 191 mg/dl by 2 h post-CO. Hematocrit increased significantly during CO exposure, but no change in plasma volume was observed. Many rats showed one-sided muscle weakness and unidirectional rotation. By 4 h post-CO, behaviorally-assessed neurologic deficit was strongly correlated with an increase in left cerebral hemisphere water content, demonstrating a direct relationship between brain edema and dysfunction resulting from CO poisoning.<p /><p>Language: en</p>",
language="en",
issn="0378-4274",
doi="",
url="http://dx.doi.org/"
}