@article{ref1,
title="Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa",
journal="Toxicon: Journal of the International Society on Toxinology",
year="1987",
author="Runnegar, M. T. and Andrews, J. and Gerdes, R. G. and Falconer, I. R.",
volume="25",
number="11",
pages="1235-1239",
abstract="The freshwater, bloom forming cyanobacterium (blue-green alga) Microcystis aeruginosa produces a peptide hepatotoxin which causes death accompanied by liver necrosis. We show here that the time and dose-dependent blebbing of isolated hepatocytes is accompanied by the activation of phosphorylase a, with no changes in cyclic AMP levels, and by glutathione (acid-soluble thiols) depletion. These results suggest that the disruption of cytoskeletal structures is accompanied by disturbances in cellular calcium homeostasis and by decreased protection against oxidative damage to the cells.<p /><p>Language: en</p>",
language="en",
issn="0041-0101",
doi="",
url="http://dx.doi.org/"
}