@article{ref1,
title="Role of physical effort in the etiology of rat heatstroke injury and mortality",
journal="Journal of applied physiology: respiratory, environmental and exercise physiology",
year="1978",
author="Hubbard, R. W. and Matthew, W. T. and Criss, R. E. and Kelly, C. and Sils, I. and Mager, M. and Bowers, W. D. and Wolfe, D.",
volume="45",
number="3",
pages="463-468",
abstract="A total of 171 untrained, unacclimatized, and unanesthetized rats were used to evaluate the effects of sedentary and work-induced hyperthermia on the incidence of mortality and cellular injury, 24 h postexposure. Cellular injury was defined as serum transaminase activity (SGPT and SGOT) exceeding 1,000 IU/l (heatstroke levels). Both the percent mortality and the percentage of 24-h survivors with transaminase levels above 1,000 IU/l were plotted against maximum core temperatures. Exertion-induced hyperthermia produced a significantly higher incidence of cellular injury and heatstroke death at lower core temperatures than hyperthermia alone. With hyperthermia only, the SGPT and SGOT dose-response curves were identical. When work was combined with hyperthermia, there was a greater incidence of elevated SGOT at lower core temperatures. These curves bore a striking resemblance to curves reflecting heat- and/or work-induced mortality in humans. The results suggest a direct role of physical effort in causing heatstroke injury and mortality.<p /><p>Language: en</p>",
language="en",
issn="0161-7567",
doi="",
url="http://dx.doi.org/"
}