@article{ref1,
title="Designer drug 5-IT -- a fatal case and analytical profiles of 5-IT and AMT",
journal="Toxichem Krimtech",
year="2013",
author="Schäper, Jan and Westphal, Folker and Fehn, Susanna",
volume="80",
number="Spec Iss",
pages="231-247",
abstract="OBJECTIVE: Recently the designer drug 5-(2-aminopropyl)indole (5-IT, 5-API) was seized by the Bavarian police on several occasions. This drug is distributed predominantly via internet as a so called research chemical (rc). 5-IT is a position isomer of alpha-methyltryptamine (AMT). Unlike 5-IT, the halluzinogenic substance AMT is listed in the German Narcotics Act (BtMG). For this reason it is necessary to distinguish between the two isomers. Case report: In this case the police discovered a light brown powder in the apartment of a de- ceased person. According to the report of the post mortem examination the cause of death re- mained unknown. <br><br>METHODS: Previously seized samples of 5-IT and AMT (in the form of research chemicals and party-pills), the light brown powder from the case mentioned above, blood and urine samples of the corpse were analyzed by LC-MS, GC-MS, GC-MS/MS, FTIR-spectroscopy and thin layer chromatography (TLC) respectively. <br><br>RESULTS and Conclusion: The mass spectra (EI 70 eV) of 5-IT and AMT are almost similar. However, these two substances can be differentiated by FTIR-spectroscopy, TLC, LC-MS, GC-MS (via TMS- and PFP-derivatives) and by GC-MS-MS after chemical ionization. Using LC-MS and GC-MS we found that the blood and urine of the deceased person contained huge amounts of 5-IT (blood level > 1,2 μg/ml). The results of the toxicological analysis led us to the conclusion that the cause of death was a fatal 5-IT-intoxication. As far as we know this is the first report of a fatal 5-IT intoxication in Germany.<p /> <p>Language: de</p>",
language="de",
issn="2190-3441",
doi="",
url="http://dx.doi.org/"
}