@article{ref1,
title="Liver damage after paracetamol and carbon tetrachloride administration",
journal="Bollettino della Società Italiana di Biologia Sperimentale",
year="1980",
author="Flaccavento, C. and Drago, A. and Pagliuca, C. and Torrielli, M. V.",
volume="56",
number="9",
pages="912-918",
abstract="Preliminary data on the liver damage following combined treatment with paracetamol and carbon tetrachloride in the rat are reported. Administration of a single dose of paracetamol (2000 mg/kg, os) was followed after 1 hour by an intraperitoneal injection of CCl4 (1.0 ml/Kg). Experiments in parallel were performed in rat given paracetamol or CCl4 alone. Our results indicate paracetamol induces a drastic decrease of hepatic GSH that appears in relation with a marked production of TBA-reacting compounds in liver tissue, while CCl4 does not modify the hepatic content of GSH and provokes a slight increase of TBA-reacting substances. Preventive treatment with paracetamol of rats intoxicated after 1 hour with carbon tetrachloride results in a partial protection against fatty liver and necrosis following haloalkane poisoning. On the other hand, the combined treatment with both the hepatotoxins was followed by a minor decrease of GSH. These data are discussed in considering a possible interaction of the two chemicals at the site of their activation.<p /><p>Language: it</p>",
language="it",
issn="0037-8771",
doi="",
url="http://dx.doi.org/"
}