@article{ref1,
title="Circulating proteasome activity following mild head injury in children",
journal="Child's nervous system",
year="2014",
author="Tylicka, Marzena and Matuszczak, Ewa and Dębek, Wojciech and Hermanowicz, Adam and Ostrowska, Halina",
volume="30",
number="7",
pages="1191-1196",
abstract="PURPOSE: The aim of the study is to characterize changes in circulating proteasome (c-proteasome) activity following mild traumatic brain injury in children. <br><br>METHODS: Fifty children managed at the Department of Pediatric Surgery because of concussion-mild head injury was randomly included into the study. The children were aged 11 months to 17 years (median = 10.07 + -1.91 years). Plasma proteasome activity was assessed using Suc-Leu-Leu-Val-Tyr-AMC peptide substrate, 2-6 h, 12-16 h, and 2 days after injury. Twenty healthy children admitted for planned inguinal hernia repair served as controls. <br><br>RESULTS: Statistically significant elevation of plasma c-proteasome activity was noted in children with mild head injury 2-6 h, 12-16 h, and 2 days after the injury. <br><br>CONCLUSIONS: Authors observed a statistically significant upward trend in the c-proteasome activity between 2-6 and 12-16 h after the mild head injury, consistent with the onset of the symptoms of cerebral concussion and a downward trend in the c-proteasome activity in the plasma of children with mild head injury between 12-16 h and on the second day after the injury, consistent with the resolving of the symptoms of cerebral concussion. Further studies are needed to demonstrate that the proteasome activity could be a prognostic factor, which can help in further diagnostic and therapeutic decisions in patients with head injury.<p /> <p>Language: en</p>",
language="en",
issn="0256-7040",
doi="10.1007/s00381-014-2409-4",
url="http://dx.doi.org/10.1007/s00381-014-2409-4"
}