@article{ref1,
title="Conditioned taste aversion to ethanol in a social context: Impact of age and sex",
journal="Behavioural brain research",
year="2014",
author="Morales, Melissa and Schatz, Kelcie C. and Anderson, Rachel I. and Spear, Linda P. and Varlinskaya, Elena I.",
volume="261",
number="",
pages="323-327",
abstract="Given that human adolescents place a high value on social interactions-particularly while consuming alcohol-the current study utilized a novel social drinking paradigm to examine rewarding and aversive properties of ethanol in non-water deprived rats that were housed and tested in groups of five same-sex littermates. On postnatal day P34 (adolescents) or P69 (adults), rats were habituated to the testing apparatus for 30min. On the next day, animals were placed into the test apparatus and given 30min access to a supersaccharin solution (3% sucrose; 0.125% saccharin), followed immediately by an intraperitoneal injection of ethanol (0, 0.25, 0.5, 1.0, and 1.5g/kg). Subsequent intake of the supersacharrin solution was assessed on three consecutive test days. Adolescent males were less sensitive to ethanol's aversive effects than adult males, with adolescent males maintaining an aversion on all three test days only at the 1.5g/kg dose, whereas adults demonstrated aversions across test days to 1 and 1.5g/kg. Adolescent females maintained aversions to 1 and 1.5g/kg across days, whereas adult females continued to show an aversion to the 1.5g/kg dose only. These opposite patterns of sensitivity that emerged among males and females at each age in the propensity to maintain an ethanol-induced taste aversion under social conditions may contribute to age- and sex-related differences in ethanol intake. Testing in social groups may be useful for future work when studying rodent models of adolescent alcohol use given the importance that human adolescents place on drinking in social settings.<p /> <p>Language: en</p>",
language="en",
issn="0166-4328",
doi="10.1016/j.bbr.2013.12.048",
url="http://dx.doi.org/10.1016/j.bbr.2013.12.048"
}