@article{ref1,
title="Brain network dysfunction in late-life depression: A literature review",
journal="Journal of geriatric psychiatry and neurology",
year="2014",
author="Tadayonnejad, Reza and Ajilore, Olusola",
volume="27",
number="1",
pages="5-12",
abstract="As a common psychiatric disorder in the growing geriatric population, late-life depression (LLD) has a negative impact on the cognitive, affective, and somatic domains of the lives of the elderly individuals. Accumulating evidence from the structural and functional imaging studies on LLD supports a &quot;network dysfunction model&quot; rather than a &quot;lesion pathology model&quot; for understanding the underlying biological mechanism in this mental disorder. In this work, we used network dysfunction model as a conceptual framework for reviewing recent neuroimaging findings in LLD. Our focus was on 4 major neurocircuits that have been shown to be involved in LLD: default mood network, cognitive control network, affective/frontolimbic network, and corticostriatal circuits. Findings of LLD-related gray and white matter structural abnormalities and resting-state and task-based functional changes were discussed for each network separately. We extended our review by summarizing the latest works that apply graph theory-based network analysis techniques for testing alterations in whole-brain network properties associated with LLD.<p /> <p>Language: en</p>",
language="en",
issn="0891-9887",
doi="10.1177/0891988713516539",
url="http://dx.doi.org/10.1177/0891988713516539"
}