@article{ref1,
title="Antidepressants, depression and suicide",
journal="Neuropsychopharmacologia Hungarica",
year="2013",
author="Rihmer, Zoltan",
volume="15",
number="3",
pages="157-164",
abstract="AIM: The goal of this paper is to analyse the complex relationship between antidepressants, depression and suicide. METHOD: Review and synthesis of the Hungarian and English language international literature, published on this topic in the last 15 years. RESULTS: Large-scale, retrospective and prospective, naturalistic (&quot;real life&quot;) studies show that compared to patients without treatment antidepressants and mood stabilizers reduce the risk of completed and attempted suicide by about 80%. This anti-suicidal potential is significantly higher than the small increase in suicidality of patients taking antidepressants in placebo controlled randomized Phase II/III trials. New data show that based on clinical data this small subgroup can be identified and successfully treated using specific therapy. CONCLUSION: Suicidal behaviour in patients taking antidepressants is mostly the consequence of the lack of antidepressant effect and is rarely the result of suicide-inducing potential of antidepressants. This rare latter case is most frequently the consequence of antidepressant monotherapy of bipolar depression. Appropriate use of antidepressants and mood stabilizers plays a key role in suicide prevention of patients with affective disorders.<p /> <p>Language: hu</p>",
language="hu",
issn="1419-8711",
doi="",
url="http://dx.doi.org/"
}