@article{ref1,
title="The fallacy of thresholds used in defining response and remission in depression rating scales",
journal="International journal of methods in psychiatric research",
year="2013",
author="Naudet, Florian and Millet, Bruno and Michel Reymann, Jean and Falissard, Bruno",
volume="23",
number="4",
pages="469-473",
abstract="Response and remission are determined by the proportion of people who fall below a threshold score on depression rating scales. This calculation implies a possibility of false positives (FP) and false negatives (FN) depending on sensitivity and specificity of the threshold used, but also on response and remission rates. A simulation illustrates the methodological consequences of this phenomenon in a comparative trial where response and remission rates differ between groups: the probability of being misclassified differs between groups, and measures of association (relative risk and odds ratio) are biased. Alternatives are proposed to cope with this misclassification bias. Copyright © 2013 John Wiley & Sons, Ltd.<p /> <p>Language: en</p>",
language="en",
issn="1049-8931",
doi="10.1002/mpr.1393",
url="http://dx.doi.org/10.1002/mpr.1393"
}