@article{ref1,
title="What can information-asymmetric games tell us about the context of Crick's 'frozen accident'?",
journal="Journal of the Royal Society, Interface",
year="2013",
author="Jee, Justin and Sundstrom, Andrew and Massey, Steven E. and Mishra, Bud",
volume="10",
number="88",
pages="20130614-20130614",
abstract="This paper describes a novel application of information-asymmetric (signalling) games to molecular biology in which utility is determined by the message complexity (rate) in addition to the error in information transfer (distortion). We show using a computational model how it is possible for the agents in one such game to evolve a signalling convention (separating equilibrium) that is suboptimal in terms of information transfer, but is nonetheless stable. In the context of an RNA world merging with a nascent amino acid one, such a game's equilibrium is alluded to by the genetic code, which is nearly optimal in terms of information transfer, but is also near-universal and nearly immutable. Such a framework suggests that cellularity may have emerged to encourage coordination between RNA species and sheds light on other aspects of RNA world biochemistry yet to be fully understood.<p /><p>Language: en</p>",
language="en",
issn="1742-5689",
doi="10.1098/rsif.2013.0614",
url="http://dx.doi.org/10.1098/rsif.2013.0614"
}