@article{ref1,
title="GABA receptors, alcohol dependence and criminal behavior",
journal="Journal of forensic sciences",
year="2013",
author="Terranova, Claudio and Tucci, Marianna and Sartore, Daniela and Cavarzeran, Fabiano and Di Pietra, Laura and Barzon, Luisa and Palù, Giorgio and Ferrara, Santo D.",
volume="58",
number="5",
pages="1227-1232",
abstract="The aim of this study was to analyze the connection between alcohol dependence and criminal behavior by an integrated genetic-environmental approach. The research, structured as a case-control study, examined 186 alcohol-dependent males; group 1 (N = 47 convicted subjects) was compared with group 2 (N = 139 no previous criminal records). Genetic results were innovative, highlighting differences in genotype distribution (p = 0.0067) in group 1 for single-nucleotide polymorphism rs 3780428, located in the intronic region of subunit 2 of the GABA B receptor gene (GABBR2). Some environmental factors (e.g., grade repetition) were associated with criminal behavior; others (e.g., attendance at Alcoholics Anonymous) were inversely related to convictions. The concomitant presence of the genetic and environmental factors found to be associated with the condition of alcohol-dependent inmate showed a 4-fold increase in the risk of antisocial behavior. The results need to be replicated on a larger population to develop new preventive and therapeutic proposals.<p /> <p>Language: en</p>",
language="en",
issn="0022-1198",
doi="10.1111/1556-4029.12201",
url="http://dx.doi.org/10.1111/1556-4029.12201"
}